SUMMARY:
Splenectomy significantly impairs the immunity of the body; in a certain proportion of the patients this may cause the so-called OPSI (Overwhelming Post-Splenectomy Infection) syndrome, i.e. incidence of fulminant life-threatening infections. Even today, despite highly efficacious sophisticated antibiotics, this condition is burdened with very high mortality. In our paper we describe the management and preventive measures in splenectomized subjects at the Department of Infectious Diseases of the Teaching Hospital Brno.